Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence
نویسندگان
چکیده
منابع مشابه
Characterization of the cytolethal distending toxin (typhoid toxin) in non-typhoidal Salmonella serovars
BACKGROUND For many putative Salmonella enterica subsp. enterica virulence genes, functional characterization across serovars has been limited. Cytolethal distending toxin B (CdtB) is an incompletely characterized virulence factor that is found not only in Salmonella enterica subsp. enterica serovar Typhi (Salmonella Typhi) and dozens of Gram negative bacterial pathogens, but also in non-typhoi...
متن کاملThe Role of Typhoid Toxin in Salmonella Typhi Virulence
Unlike many of the nontyphoidal Salmonella serovars such as S. Typhimurium that cause restricted gastroenteritis, Salmonella Typhi is unique in that it causes life-threatening typhoid fever in humans. Despite the vast difference in disease outcomes that S. Typhi and S. Typhimurium cause in humans, there are few genomic regions that are unique to S. Typhi. Of these regions, the most notable is t...
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ABSTRACT The epidemiological studies indicate that the incidence of salmonellosis is increasing throughout the world. The uncontroled and unappropriate usage of antibiotics has been caused multi - drug resistance in these organisms, in recent years. In a cross-sectional descriptive study, 204 strains of typhoidal salmonella (T.S) and 114 strains of non-typhoidal salmonella (N.T.S) were exami...
متن کاملNon-typhoidal Salmonella bacteremia in adults.
BACKGROUND AND PURPOSE Very few studies have examined prognostic factors in adult patients with non-typhoidal Salmonella (NTS) bacteremia. The purpose of this study was to identify the prognostic factors of these patients. METHODS A total of 79 episodes of NTS bacteremia were identified in 73 patients between January 2001 and December 2003. Susceptibilities to various antimicrobials were dete...
متن کاملTyphoidal Salmonella and Emerging Resistance in Outbreak Proportions
Introduction: Typhoidal Salmonella causes an invasive infection resulting in 200 000 deaths among 20 million patients annually. Typhoid remains a public health problem in Southeast Asia, the Indian subcontinent, Africa, and South America. Traveler’s diarrhea caused by Salmonella is common in Asia. Outbreaks of typhoidal Salmonella resistant to ampicillin, chloramphenicol, and t...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2020
ISSN: 1931-3128
DOI: 10.1016/j.chom.2020.04.005